diff --git a/CHANGELOG.md b/CHANGELOG.md
index a78eabf786..7d8b955eb1 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -13,6 +13,7 @@ This project adheres to [Semantic Versioning](https://semver.org/).
 ## Fixed
 - [#3690](https://github.com/plotly/dash/pull/3690) Fixes Input when min or max is set to None
 - [#3723](https://github.com/plotly/dash/pull/3723) Fix misaligned `dcc.Slider` marks when some labels are empty strings
+- [#3740](https://github.com/plotly/dash/pull/3740) Fix cannot tab into dropdowns in Safari
 
 ## [4.1.0] - 2026-03-23
 
diff --git a/components/dash-core-components/src/components/css/dropdown.css b/components/dash-core-components/src/components/css/dropdown.css
index 5667b85060..6a74a79df0 100644
--- a/components/dash-core-components/src/components/css/dropdown.css
+++ b/components/dash-core-components/src/components/css/dropdown.css
@@ -55,6 +55,12 @@
     cursor: not-allowed;
 }
 
+.dash-dropdown-focus-target {
+    position: absolute;
+    opacity: 0;
+    pointer-events: none;
+}
+
 .dash-dropdown-value {
     max-width: 100%;
     text-align: left;
diff --git a/components/dash-core-components/src/fragments/Dropdown.tsx b/components/dash-core-components/src/fragments/Dropdown.tsx
index 6a838fb1df..cc3f1f230c 100644
--- a/components/dash-core-components/src/fragments/Dropdown.tsx
+++ b/components/dash-core-components/src/fragments/Dropdown.tsx
@@ -313,6 +313,7 @@ const Dropdown = (props: DropdownProps) => {
             const relevantKeys = [
                 'ArrowDown',
                 'ArrowUp',
+                'Tab',
                 'PageDown',
                 'PageUp',
                 'Home',
@@ -342,6 +343,19 @@ const Dropdown = (props: DropdownProps) => {
             let nextIndex: number;
 
             switch (e.key) {
+                case 'Tab': {
+                    // Trap Tab inside the popover so Safari (which
+                    // skips non-text inputs) can navigate options.
+                    const next = current + (e.shiftKey ? -1 : 1);
+                    if (next < minIndex) {
+                        nextIndex = maxIndex;
+                    } else if (next > maxIndex) {
+                        nextIndex = minIndex;
+                    } else {
+                        nextIndex = next;
+                    }
+                    break;
+                }
                 case 'ArrowDown':
                     nextIndex = current < maxIndex ? current + 1 : minIndex;
                     break;
@@ -408,12 +422,37 @@ const Dropdown = (props: DropdownProps) => {
 
     const popover = (
         <Popover.Root open={isOpen} onOpenChange={handleOpenChange}>
+            {/* Safari skips <button> in the Tab order; this hidden
+                input receives Tab focus and delegates to the button. */}
+            <input
+                className="dash-dropdown-focus-target"
+                tabIndex={disabled ? -1 : 0}
+                readOnly
+                aria-hidden="true"
+                onFocus={e => {
+                    if (e.relatedTarget !== dropdownContainerRef.current) {
+                        e.currentTarget.tabIndex = -1;
+                        dropdownContainerRef.current?.focus();
+                    }
+                }}
+                onClick={() => {
+                    dropdownContainerRef.current?.click();
+                }}
+            />
             <Popover.Trigger asChild>
                 <button
                     id={id}
                     ref={dropdownContainerRef}
                     disabled={disabled}
                     type="button"
+                    tabIndex={-1}
+                    onBlur={e => {
+                        const dummyInput =
+                            e.currentTarget.previousElementSibling;
+                        if (dummyInput instanceof HTMLElement) {
+                            dummyInput.tabIndex = 0;
+                        }
+                    }}
                     onKeyDown={e => {
                         if (['ArrowDown', 'Enter'].includes(e.key)) {
                             e.preventDefault();
diff --git a/components/dash-core-components/tests/integration/calendar/test_date_picker_single.py b/components/dash-core-components/tests/integration/calendar/test_date_picker_single.py
index 67d68411ca..e679f61a1a 100644
--- a/components/dash-core-components/tests/integration/calendar/test_date_picker_single.py
+++ b/components/dash-core-components/tests/integration/calendar/test_date_picker_single.py
@@ -142,7 +142,9 @@ def test_dtps012_initial_visible_month(dash_dcc):
 
     # Check that calendar shows January 2010 (initial_visible_month), not June 2020 (date)
     month_dropdown = dash_dcc.find_element(".dash-datepicker-controls .dash-dropdown")
-    year_input = dash_dcc.find_element(".dash-datepicker-controls input")
+    year_input = dash_dcc.find_element(
+        ".dash-datepicker-controls input:not([aria-hidden])"
+    )
 
     assert "January" in month_dropdown.text, "Calendar should show January"
     assert year_input.get_attribute("value") == "2010", "Calendar should show year 2010"
diff --git a/components/dash-core-components/tests/integration/calendar/test_portal.py b/components/dash-core-components/tests/integration/calendar/test_portal.py
index f8ddfb3108..7632dfcf61 100644
--- a/components/dash-core-components/tests/integration/calendar/test_portal.py
+++ b/components/dash-core-components/tests/integration/calendar/test_portal.py
@@ -28,7 +28,9 @@ def click_everything_in_datepicker(datepicker_id, dash_dcc):
         )
     )
 
-    interactive_elements.extend(popover.find_elements(By.CSS_SELECTOR, "input"))
+    interactive_elements.extend(
+        popover.find_elements(By.CSS_SELECTOR, "input:not([aria-hidden])")
+    )
 
     buttons = reversed(
         popover.find_elements(By.CSS_SELECTOR, "button")
diff --git a/components/dash-core-components/tests/integration/dropdown/test_a11y.py b/components/dash-core-components/tests/integration/dropdown/test_a11y.py
index 5db929bc08..e5199fe248 100644
--- a/components/dash-core-components/tests/integration/dropdown/test_a11y.py
+++ b/components/dash-core-components/tests/integration/dropdown/test_a11y.py
@@ -653,6 +653,96 @@ def update_output(search_value):
     assert dash_duo.get_logs() == []
 
 
+def test_a11y012b_tab_from_search_focuses_first_option(dash_duo):
+    def send_keys(key):
+        actions = ActionChains(dash_duo.driver)
+        actions.send_keys(key)
+        actions.perform()
+
+    app = Dash(__name__)
+    app.layout = Div(
+        [
+            Dropdown(
+                id="dropdown",
+                options=["Apple", "Banana", "Cherry"],
+                searchable=True,
+            ),
+            Div(id="output"),
+        ]
+    )
+
+    @app.callback(Output("output", "children"), Input("dropdown", "value"))
+    def update_output(value):
+        return f"Selected: {value}"
+
+    dash_duo.start_server(app)
+
+    dropdown = dash_duo.find_element("#dropdown")
+    dropdown.send_keys("b")
+
+    dash_duo.wait_for_element(".dash-dropdown-search")
+
+    # Tab from search input should focus the first option
+    send_keys(Keys.TAB)
+    sleep(0.1)
+
+    # The dropdown should still be open
+    dash_duo.wait_for_element(".dash-dropdown-options")
+
+    # Enter selects the focused option
+    send_keys(Keys.ENTER)
+    dash_duo.wait_for_text_to_equal("#output", "Selected: Banana")
+
+    assert dash_duo.get_logs() == []
+
+
+def test_a11y012c_shift_tab_between_dropdowns(dash_duo):
+    """Shift+Tab should move between dropdowns in a single press,
+    just like forward Tab does."""
+    from dash.html import Button as HtmlButton
+
+    def shift_tab():
+        actions = ActionChains(dash_duo.driver)
+        actions.key_down(Keys.SHIFT).send_keys(Keys.TAB).key_up(Keys.SHIFT)
+        actions.perform()
+
+    app = Dash(__name__)
+    app.layout = Div(
+        [
+            Dropdown(
+                id="dd1",
+                options=["Apple", "Banana"],
+            ),
+            Dropdown(
+                id="dd2",
+                options=["Cherry", "Date"],
+            ),
+            HtmlButton("after", id="after"),
+        ]
+    )
+
+    dash_duo.start_server(app)
+    dash_duo.wait_for_element("#dd1")
+
+    # Focus the button at the end
+    dash_duo.find_element("#after").click()
+    sleep(0.1)
+
+    # Shift+Tab once should reach dd2
+    shift_tab()
+    sleep(0.1)
+    active = dash_duo.driver.execute_script("return document.activeElement.id;")
+    assert active == "dd2", f"Expected dd2 but got {active}"
+
+    # Shift+Tab once more should reach dd1
+    shift_tab()
+    sleep(0.1)
+    active = dash_duo.driver.execute_script("return document.activeElement.id;")
+    assert active == "dd1", f"Expected dd1 but got {active}"
+
+    assert dash_duo.get_logs() == []
+
+
 def test_a11y013_enter_on_search_after_reopen_selects_correctly(dash_duo):
     def send_keys(key):
         actions = ActionChains(dash_duo.driver)
diff --git a/components/dash-core-components/tests/integration/misc/test_popover_visibility.py b/components/dash-core-components/tests/integration/misc/test_popover_visibility.py
index 3857921545..993892f9fb 100644
--- a/components/dash-core-components/tests/integration/misc/test_popover_visibility.py
+++ b/components/dash-core-components/tests/integration/misc/test_popover_visibility.py
@@ -25,7 +25,9 @@ def click_everything_in_datepicker(datepicker_id, dash_dcc):
         )
     )
     interactive_elements.extend(popover.find_elements(By.CSS_SELECTOR, "button"))
-    interactive_elements.extend(popover.find_elements(By.CSS_SELECTOR, "input"))
+    interactive_elements.extend(
+        popover.find_elements(By.CSS_SELECTOR, "input:not([aria-hidden])")
+    )
     for el in interactive_elements:
         try:
             el.click()