diff --git a/doc/api/sqlite.md b/doc/api/sqlite.md
index 2f3111432be5a6..e4ba433e913ef0 100644
--- a/doc/api/sqlite.md
+++ b/doc/api/sqlite.md
@@ -631,10 +631,14 @@ added: v22.5.0
     database options or `true`.
   * `allowUnknownNamedParameters` {boolean} If `true`, unknown named parameters
     are ignored. **Default:** inherited from database options or `false`.
+  * `persistent` {boolean} If `true`, hints to SQLite that this statement will
+    be reused many times, causing it to use a different memory allocation
+    strategy that reduces heap fragmentation. Corresponds to the
+    [`SQLITE_PREPARE_PERSISTENT`][] flag. **Default:** `false`.
 * Returns: {StatementSync} The prepared statement.
 
 Compiles a SQL statement into a [prepared statement][]. This method is a wrapper
-around [`sqlite3_prepare_v2()`][].
+around [`sqlite3_prepare_v3()`][].
 
 ### `database.createTagStore([maxSize])`
 
@@ -1625,6 +1629,7 @@ callback function to indicate what type of operation is being authorized.
 [`SQLITE_DETERMINISTIC`]: https://www.sqlite.org/c3ref/c_deterministic.html
 [`SQLITE_DIRECTONLY`]: https://www.sqlite.org/c3ref/c_deterministic.html
 [`SQLITE_MAX_FUNCTION_ARG`]: https://www.sqlite.org/limits.html#max_function_arg
+[`SQLITE_PREPARE_PERSISTENT`]: https://sqlite.org/c3ref/c_prepare_dont_log.html#sqlitepreparepersistent
 [`SQLTagStore`]: #class-sqltagstore
 [`database.applyChangeset()`]: #databaseapplychangesetchangeset-options
 [`database.createTagStore()`]: #databasecreatetagstoremaxsize
@@ -1649,7 +1654,7 @@ callback function to indicate what type of operation is being authorized.
 [`sqlite3_get_autocommit()`]: https://sqlite.org/c3ref/get_autocommit.html
 [`sqlite3_last_insert_rowid()`]: https://www.sqlite.org/c3ref/last_insert_rowid.html
 [`sqlite3_load_extension()`]: https://www.sqlite.org/c3ref/load_extension.html
-[`sqlite3_prepare_v2()`]: https://www.sqlite.org/c3ref/prepare.html
+[`sqlite3_prepare_v3()`]: https://www.sqlite.org/c3ref/prepare.html
 [`sqlite3_serialize()`]: https://sqlite.org/c3ref/serialize.html
 [`sqlite3_set_authorizer()`]: https://sqlite.org/c3ref/set_authorizer.html
 [`sqlite3_sql()`]: https://www.sqlite.org/c3ref/expanded_sql.html
diff --git a/src/node_sqlite.cc b/src/node_sqlite.cc
index 4d1a35d753230a..2b4700cdb02ea4 100644
--- a/src/node_sqlite.cc
+++ b/src/node_sqlite.cc
@@ -1441,6 +1441,7 @@ void DatabaseSync::Prepare(const FunctionCallbackInfo<Value>& args) {
   std::optional<bool> use_big_ints;
   std::optional<bool> allow_bare_named_params;
   std::optional<bool> allow_unknown_named_params;
+  std::optional<bool> persistent;
 
   if (args.Length() > 1 && !args[1]->IsUndefined()) {
     if (!args[1]->IsObject()) {
@@ -1521,11 +1522,31 @@ void DatabaseSync::Prepare(const FunctionCallbackInfo<Value>& args) {
       }
       allow_unknown_named_params = allow_unknown_named_params_v->IsTrue();
     }
+
+    Local<Value> persistent_v;
+    if (!options
+             ->Get(env->context(),
+                   FIXED_ONE_BYTE_STRING(env->isolate(), "persistent"))
+             .ToLocal(&persistent_v)) {
+      return;
+    }
+    if (!persistent_v->IsUndefined()) {
+      if (!persistent_v->IsBoolean()) {
+        THROW_ERR_INVALID_ARG_TYPE(
+            env->isolate(),
+            "The \"options.persistent\" argument must be a boolean.");
+        return;
+      }
+      persistent = persistent_v->IsTrue();
+    }
   }
 
   Utf8Value sql(env->isolate(), args[0].As<String>());
   sqlite3_stmt* s = nullptr;
-  int r = sqlite3_prepare_v2(db->connection_, *sql, -1, &s, nullptr);
+  unsigned int prep_flags =
+      persistent.value_or(false) ? SQLITE_PREPARE_PERSISTENT : 0;
+  int r =
+      sqlite3_prepare_v3(db->connection_, *sql, -1, prep_flags, &s, nullptr);
 
   CHECK_ERROR_OR_THROW(env->isolate(), db, r, SQLITE_OK, void());
   BaseObjectPtr<StatementSync> stmt =
@@ -3531,8 +3552,12 @@ BaseObjectPtr<StatementSync> SQLTagStore::PrepareStatement(
 
   if (stmt == nullptr) {
     sqlite3_stmt* s = nullptr;
-    int r = sqlite3_prepare_v2(
-        session->database_->connection_, sql.data(), sql.size(), &s, nullptr);
+    int r = sqlite3_prepare_v3(session->database_->connection_,
+                               sql.data(),
+                               sql.size(),
+                               SQLITE_PREPARE_PERSISTENT,
+                               &s,
+                               nullptr);
 
     if (r != SQLITE_OK) {
       THROW_ERR_SQLITE_ERROR(isolate, session->database_.get());
diff --git a/test/parallel/test-sqlite-statement-sync.js b/test/parallel/test-sqlite-statement-sync.js
index aa7a3a73ae6649..842faea14cc434 100644
--- a/test/parallel/test-sqlite-statement-sync.js
+++ b/test/parallel/test-sqlite-statement-sync.js
@@ -909,3 +909,46 @@ suite('options.allowBareNamedParameters', () => {
     );
   });
 });
+
+suite('options.persistent', () => {
+  test('statement executes correctly when persistent is true', (t) => {
+    const db = new DatabaseSync(nextDb());
+    t.after(() => { db.close(); });
+    db.exec('CREATE TABLE data(key INTEGER PRIMARY KEY, val INTEGER) STRICT;');
+    db.exec('INSERT INTO data (key, val) VALUES (1, 42);');
+    const stmt = db.prepare('SELECT val FROM data', { persistent: true });
+    t.assert.deepStrictEqual(stmt.get(), { __proto__: null, val: 42 });
+  });
+
+  test('statement executes correctly when persistent is false', (t) => {
+    const db = new DatabaseSync(nextDb());
+    t.after(() => { db.close(); });
+    db.exec('CREATE TABLE data(key INTEGER PRIMARY KEY, val INTEGER) STRICT;');
+    db.exec('INSERT INTO data (key, val) VALUES (1, 42);');
+    const stmt = db.prepare('SELECT val FROM data', { persistent: false });
+    t.assert.deepStrictEqual(stmt.get(), { __proto__: null, val: 42 });
+  });
+
+  test('throws when input is not a boolean', (t) => {
+    const db = new DatabaseSync(nextDb());
+    t.after(() => { db.close(); });
+    t.assert.throws(() => {
+      db.prepare('SELECT 1', { persistent: 'yes' });
+    }, {
+      code: 'ERR_INVALID_ARG_TYPE',
+      message: /The "options\.persistent" argument must be a boolean/,
+    });
+  });
+
+  test('can be combined with other options', (t) => {
+    const db = new DatabaseSync(nextDb());
+    t.after(() => { db.close(); });
+    db.exec('CREATE TABLE data(key INTEGER PRIMARY KEY, val INTEGER) STRICT;');
+    db.exec('INSERT INTO data (key, val) VALUES (1, 42);');
+    const stmt = db.prepare(
+      'SELECT val FROM data',
+      { persistent: true, readBigInts: true }
+    );
+    t.assert.deepStrictEqual(stmt.get(), { __proto__: null, val: 42n });
+  });
+});